Why trust our testing? We spent weeks evaluating the largest self-cleaning litter boxes, focusing on capacity, reliability, and ease of cleaning. Our team of veterinary professionals and product testers looked for models that minimize odor, reduce scooping, and accommodate big or multiple cats. We compared each unit against published specifications and aggregated real owner experiences. What we found: While no litter box is perfect, several large self-cleaning models stand out for their spacious interiors, smart features, and solid waste management. Our top picks balance performance and value, with particular attention to safety and maintenance. Whether you own a Maine Coon or a multi-cat household, we have a recommendation that fits your needs.