🏆 Complete Buyer's Guide · Dog Care Products

Why Small Dogs Need Enzymatic Toothpaste: 5 Best Picks for 2026

Crowded teeth make small dogs under 20 lbs prone to dental disease. See why enzymatic formulas like Virbac C.E.T. Poultry are top choices for plaque control.

PE
ProPawPicks Editorial Team
ProPawPicks Reviewer
Updated

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Virbac C.E.T. Enzymatic Toothpaste, Poultry Flavor ★ Top Pick: Virbac C.E.T. Enzymatic Toothpaste, Poultry Flavor Check Price on Amazon →
80%
Plaque reduction with regular use (enzymatic toothpaste)
1 in 3
Small dogs have dental disease by age 3
12 oz
Average tube size for small breed toothpaste
2 min
Recommended brushing time per session
⚡ Key takeaways
  • Best Overall: Virbac C.E.T. Enzymatic Toothpaste, Poultry Flavor. This toothpaste leads with a dual-enzyme system (glucose oxidase and lactoperoxidase) that.
  • Best for Sensitive Gums: Vet's Best Enzymatic Dog Toothpaste. Formulated with aloe vera, neem oil, and grapefruit seed extract, this toothpaste soothes.
  • Best Budget: Nylabone Advanced Oral Care Dog Toothpaste. Offering enzymatic cleaning at a lower price point, Nylabone's toothpaste includes a tripl.
  • Best No-Brush Option: TropiClean Fresh Breath No Brushing Dental Gel. This gel is designed for dogs that resist brushing.
  • Best for Plaque Control: Petsmile Professional Pet Toothpaste, Chicken Flavor. Petsmile's formula is the only dog toothpaste with the VOHC seal for plaque control.
At a Glance

Quick Comparison

ProductBest For
Virbac C.E.T. Enzymatic Toothpaste, Poultry F… Best Overall Check price →
Vet's Best Enzymatic Dog Toothpaste Best for Sensitive Gums Check price →
Nylabone Advanced Oral Care Dog Toothpaste Best Budget Check price →
TropiClean Fresh Breath No Brushing Dental Gel Best No-Brush Option Check price →
Petsmile Professional Pet Toothpaste, Chicken… Best for Plaque Control Check price →

Quick answer

The best dog toothpaste for dogs under 20 lbs is Virbac C.E.T. Enzymatic Toothpaste in poultry flavor. It uses a dual-enzyme system to break down plaque and tartar, and its small dog-friendly formula is safe if swallowed. For a budget-friendly option, Nylabone Advanced Oral Care Toothpaste offers similar enzymatic action at a lower price. If your dog has sensitive gums, the Vet’s Best Enzymatic Toothpaste includes aloe vera and neem oil for soothing relief.

What to consider for Dog Toothpaste For Dogs Under 20 Lbs

Small dogs are prone to dental issues due to their crowded teeth. Look for a toothpaste with enzymatic action (glucose oxidase and lactoperoxidase) that works without brushing. Avoid human toothpaste because it contains xylitol, which is toxic to dogs. Choose a flavor your dog enjoys, such as poultry, beef, or peanut butter, to make brushing easier. The toothpaste should be free of artificial colors, preservatives, and foaming agents. A soft-bristled brush sized for small mouths is also important.

What to look for in a grooming product (shampoo, brush, clipper or wipe)

For dog toothpaste, the key features are enzymatic formula, safe ingredients (no xylitol), palatable flavor, and a texture that adheres to teeth. For other grooming products, consider: a match for the dog’s coat type (slicker brush for long hair, bristle brush for short hair), gentle dog-safe ingredients with a suitable pH for sensitive skin (look for oatmeal or aloe), quality blades or bristles that won’t pull or snag, low noise for nervous dogs (especially clippers), and ease of use (ergonomic handles, easy-clean design).

How we chose these picks

  • We prioritized enzymatic toothpaste with proven plaque-fighting ingredients.
  • We selected products specifically marketed for small dogs or safe for all sizes.
  • We checked that each toothpaste is free of xylitol, fluoride, and other harmful additives.
  • We considered flavor variety and palatability based on customer feedback.
  • We evaluated the reputation and transparency of the brand.
  • We looked at price per ounce to ensure value.
  • We read user reviews for real-world effectiveness and ease of use.
  • Never ranked a product higher just because it pays a commission.

What to avoid

  • Human toothpaste: contains xylitol (toxic to dogs) and fluoride (can cause stomach upset).
  • Harsh fragrances or artificial sweeteners; they can irritate a dog’s sensitive mouth.
  • Toothpaste that foams; dogs can’t spit, so foam may cause drooling or stress.
  • Brushing too aggressively; small dogs have delicate gums that can bleed easily.

For more on keeping your dog healthy, check out our dog guides, dog health, and dog care products.

Why this matters

Small dogs under 20 pounds are at higher risk for dental disease because their teeth are crowded, making plaque removal more difficult. Enzymatic toothpaste that works chemically can be especially beneficial for these breeds.

The Options

Types Explained

Enzymatic Toothpaste

Contains enzymes that chemically break down plaque and tartar. Most effective for daily maintenance. Suitable for all small breeds.

Best for: Daily plaque control and freshening breath

Non-Enzymatic Toothpaste

Relies on mechanical scrubbing and ingredients like baking soda or silica. May be less effective than enzymatic types but can still help.

Best for: Dogs that tolerate brushing well and need mild cleaning

Dental Gel

A gel that can be applied directly to teeth or added to water. Often no-brush required, making it convenient for anxious dogs.

Best for: Dogs that resist brushing; maintenance between brushings

Dental Wipes

Pre-moistened wipes with cleaning agents to wipe teeth and gums. Easy to use but less effective than paste for deep cleaning.

Best for: Quick freshening on the go or for dogs that dislike brushes
The Rankings

Top 5 Picks

#1
Virbac C.E.T. Enzymatic Toothpaste, Poultry Flavor
Best Overall

Virbac C.E.T. Enzymatic Toothpaste, Poultry Flavor

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This toothpaste leads with a dual-enzyme system (glucose oxidase and lactoperoxidase) that actively breaks down plaque and tartar, even without brushing. Its poultry flavor is highly palatable for small dogs. The formula is free of xylitol and safe if swallowed. One limitation is the price; it's slightly more expensive per ounce than some competitors, but the proven efficacy justifies the cost.

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#2
Vet's Best Enzymatic Dog Toothpaste
Best for Sensitive Gums

Vet's Best Enzymatic Dog Toothpaste

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Formulated with aloe vera, neem oil, and grapefruit seed extract, this toothpaste soothes sensitive gums while fighting plaque. It uses a natural enzymatic action that is gentle yet effective. The mild flavor appeals to picky eaters. However, it has a thinner consistency than some pastes, which may require a bit more attention to keep on the brush.

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#3
Nylabone Advanced Oral Care Dog Toothpaste
Best Budget

Nylabone Advanced Oral Care Dog Toothpaste

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Offering enzymatic cleaning at a lower price point, Nylabone's toothpaste includes a triple enzyme formula to combat plaque and freshen breath. It's available in tasty flavors like beef and poultry. The tube is smaller, but the value per ounce is excellent. A drawback is that some dogs dislike the texture, but most small breed owners report positive results.

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#4
TropiClean Fresh Breath No Brushing Dental Gel
Best No-Brush Option

TropiClean Fresh Breath No Brushing Dental Gel

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This gel is designed for dogs that resist brushing. Simply apply it to the teeth or add to water; its enzymes help reduce plaque and tartar with minimal effort. It's free of artificial colors and preservatives. The downside is that it may be less effective than traditional toothpaste for heavy tartar buildup, but it's a great maintenance product for small dogs.

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#5
Petsmile Professional Pet Toothpaste, Chicken Flavor
Best for Plaque Control

Petsmile Professional Pet Toothpaste, Chicken Flavor

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Petsmile's formula is the only dog toothpaste with the VOHC seal for plaque control. It uses Calprox, a proprietary ingredient that helps remove plaque and prevent tartar. The chicken flavor is well-liked, and the toothpaste is safe if swallowed. The main trade-off is the higher cost, but the clinical backing makes it a top choice for dental health.

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Before You Buy

Key Buying Factors

01

Enzymatic Formula

Enzymatic toothpastes contain glucose oxidase and lactoperoxidase that help break down plaque and tartar chemically, reducing reliance on mechanical brushing. This is especially beneficial for small dogs with crowded teeth.

02

Safety and Ingredients

Avoid xylitol, fluoride, and artificial foaming agents. Look for natural ingredients like aloe vera, neem oil, or green tea extract that soothe gums and fight bacteria. The toothpaste should be safe if swallowed.

03

Flavor Palatability

Small dogs can be picky. Popular flavors include poultry, beef, peanut butter, and mint. A flavor your dog likes makes brushing less stressful and more effective.

04

Texture and Consistency

Some toothpastes are paste-like, others are gel. Paste may adhere better to the brush and teeth, while gel can be easier to apply. Choose based on your dog's preference and your brushing technique.

05

Veterinary Approval

Look for products with the Veterinary Oral Health Council (VOHC) seal or recommendations from veterinary dental societies. This indicates the product has met standards for plaque and tartar control.

Living With It

Care, Cost and Maintenance

Brushing Technique

Use a soft-bristled toothbrush designed for small dogs. Apply a pea-sized amount of toothpaste. Gently brush in circular motions along the gumline, focusing on the back teeth where plaque accumulates. Brush for about 2 minutes, ideally once daily.

Introducing Toothpaste

Let your dog lick a small amount of toothpaste from your finger first. Gradually introduce the brush, allowing them to chew on it. Reward with praise. Consistency and patience are key; never force the brush.

Frequency and Routine

Daily brushing is ideal, but 3 to 4 times per week can still make a difference. Pair with dental chews or water additives for extra protection. Regular veterinary dental check-ups are also important for small breeds.

Pro tip

To make brushing easier, let your dog lick a small amount of toothpaste from the brush as a reward before each session. This builds positive association and reduces resistance.

Frequently asked questions

How often should I brush my small dog's teeth?
Daily brushing is recommended for optimal dental health. Small dogs are especially prone to plaque buildup due to crowded teeth, so consistent care is important. If daily isn't possible, aim for at least three to four times per week. Supplement with dental chews or water additives on off days to help reduce tartar. Regular veterinary dental cleanings are also advised.
Can I use human toothpaste on my dog?
No, never use human toothpaste on dogs. Human toothpaste often contains xylitol, a sweetener that is toxic to dogs and can cause rapid insulin release, leading to hypoglycemia. It may also contain fluoride, which can cause stomach upset if swallowed. Always use a dog-specific enzymatic toothpaste that is safe to ingest.
What ingredients should I look for in dog toothpaste?
Look for enzymatic ingredients such as glucose oxidase and lactoperoxidase, which help break down plaque. Natural soothing ingredients like aloe vera, neem oil, and green tea extract are beneficial for sensitive gums. Avoid xylitol, fluoride, artificial colors, and harsh abrasives. Some toothpastes include baking soda for gentle cleaning, but it should be used sparingly.
Is it necessary to use a special toothbrush for small dogs?
Yes, using a toothbrush sized for small dogs is important. Human toothbrushes are too large and can cause discomfort or injury. Small dog toothbrushes have softer bristles and a smaller head to fit their mouths. Finger brushes are also an option for dogs that resist a traditional brush, but they may not clean as effectively.
My dog hates having its teeth brushed. What can I do?
Start by letting your dog taste the toothpaste from your finger. Gradually introduce a finger brush or soft toothbrush with a small amount of toothpaste. Keep sessions short and positive, offering treats and praise. Some dogs prefer dental gels that don't require brushing. Consistency and patience are key; never force the brush.
How does enzymatic toothpaste work without brushing?
Enzymatic toothpaste contains enzymes like glucose oxidase and lactoperoxidase that react with saliva to produce low levels of hydrogen peroxide, which helps break down plaque and kill bacteria. While brushing enhances contact and mechanical removal, some enzymatic toothpastes can still provide benefits when applied directly to teeth or via a finger.
Are dental treats enough to clean my dog's teeth?
Dental treats can help reduce plaque and tartar, but they are not a substitute for brushing. They work through mechanical abrasion and may contain enzymes. However, they often don't reach the gumline or back teeth effectively. For best results, combine treats with regular brushing and professional cleanings as recommended by your veterinarian.
What is the best way to prevent dental disease in small dogs?
The best prevention is a combination of daily brushing with enzymatic toothpaste, regular veterinary dental check-ups (at least once a year), and a healthy diet. Dental chews and water additives can provide additional support. Small breeds often require more frequent professional cleanings due to their crowded teeth.
Can dog toothpaste expire?
Yes, dog toothpaste typically has an expiration date printed on the tube. Using expired toothpaste may reduce its effectiveness, as enzymes and other active ingredients can degrade over time. Store toothpaste in a cool, dry place and replace it if it changes in smell, color, or consistency.
A note on advice: This guide is general information, not a substitute for professional veterinary advice. Talk to your vet before changing your pet's diet or care routine, especially if your pet has allergies, kidney disease, pancreatitis, obesity, heart disease or any other medical condition.
Transparency

How we made this guide

How we chose. We compared the options on the factors that matter most for Dog Care Products, using manufacturer specifications, aggregated verified owner reviews and editorial comparison. We rank independently: no brand pays for placement, and affiliate commissions never influence our picks.

How it was written. This guide was researched, reviewed and edited by the ProPawPicks editorial team for accuracy and usefulness. We have not personally tested every product; where we have not, rankings rely on verified specs, owner feedback and expert comparison rather than a hands-on review.

Affiliate disclosure. ProPawPicks is reader-supported. If you buy through links on our site, we may earn a commission at no extra cost to you. See our affiliate disclosure.

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Sources and further reading

Some links below are affiliate links. If you buy through them we may earn a small commission at no extra cost to you. Our rankings are based on product research, label data and suitability, not on commissions.